Tujuan kajian ini adalah terdeskripsikannya jumlah pengidap HIV dan AIDS, terdeskripsikan faktor penyebab, dan dampak tertularnya HIV dan AIDS. Sifat kajian ini deskriptif, dengan pendekatan menggunakan studi dokumen. Tehnik analisa data yang dipergunakan adalah tehnik deskriptif kualitatif. Hasil kajian menunjukkan bahwa jumlah, pengidap HIV dan AIDS di DIY, jumlah HIV 3.334 kasus dan AIDS sebanyak 1.314 kasus, sebagian besar yang terkena kasus jenis kelamin laki-laki. Jumlah kasus yang ada tersebut yang telah meninggal dikarenakan HIV sebanyak 283 orang dan AIDS sebanyak 181 orang. Berdasarkan data sampai dengan maret tahun 2016 tingkat penyebaran HIV dan AIDS di DIY tertinggi di Kabupaten Sleman. sedangkan pada tahun 2014 peringkat tertinggi Kota Yogyakarta ini diartikan mengalami pergeseran. Direkomendasikan: upaya untuk meningkatkan penanggulangan dengan meningkatkan pencegahan dan penanganan agar lebih efektif dan efisien dengan melibatkan berbagai elemen terkait dari tingkat pusat maupun daerah, antara lain seperti Kementerian Sosial, Kementerian Kesehatan, Kementerian Hukum dan HAM, Kementerian Pendidikan dan Kebudayaan RI, Komisi Penanggulangan AIDS, Kementerian Pemberdayaan Perempuan Dan Perlindungan Anak, Kepolisian, dan Badan Narkotika Nasional (BNN).
Kata Kunci: DIY, Rentan, HIV dan AIDS.

The purpose of this study is to describe the number of people with HIV and AIDS, describing the causes, and the impact of HIV and AIDS. The nature of this study is descriptive, with an approach using document study. The data analysis technique used is qualitative descriptive techniques. The results of the study showed that the number, people with HIV and AIDS in DIY, the number of HIV 3,334 cases and AIDS as many as 1,314 cases, most of which were affected by cases of male sex. The number of cases that have died is due to HIV as many as 283 people and AIDS as many as 181 people. Based on data up to March 2016 the rate of spread of HIV and AIDS in DIY was the highest in Sleman Regency, whereas in 2014 the highest ranking of Yogyakarta City was interpreted as a shift. Recommended: efforts to improve countermeasures by increasing prevention and handling to be more effective and efficient by involving various relevant elements from the central and regional levels, such as the Ministry of Social Affairs, Ministry of Health, Ministry of Law and Human Rights, Ministry of Education and Culture, AIDS Commission, Ministry of Women's Empowerment and Child Protection, Police, and National Narcotics Agency (BNN).
Keywords: DIY, Vulnerable, HIV and AIDS.