Electronic Resource

New gold-catalyzed reactions and applications for the synthesis of alkaloids

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Ana Escribano Cuesta's thesis presents a detailed study of the inter- and intramolecular reactions of carbonyl compounds with 1,6-enynes using gold (I) complexes. An important part of the work involved streamlining the variables that allow the selective synthesis of different products such as tricyclic compounds, dihydropyrans, 1,3-dienes or cyclobutenes. The second chapter highlights the importance and difficulties in synthesising a cyclobutene subunit and the author includes a detailed description of how the products were prepared. The final chapter outlines the synthesis of lundurines using methodology developed by the author's research group for intramolecular gold-catalyzed cyclization of indoles with alkynes. The lundurine products developed in this work show significant in vitro cytoxicity toward B16 melanoma cells. The work in this thesis has led to a number of publications in high-profile chemistry journals.

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Ketersediaan

Informasi Detail

Judul Seri

Springer Theses

No. Panggil

E205

Penerbit

Cham : Springer., 2013

Deskripsi Fisik

XIII, 195 lembar

Bahasa

English

ISBN/ISSN

9783319007021

Klasifikasi

NONE

Tipe Isi

text

Tipe Media

computer

Tipe Pembawa

online resource

Edisi

-

Subjek

Katalisis
Sintesis Alkaloid

Info Detail Spesifik

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Pernyataan Tanggungjawab

Ana Escribano Cuesta

Versi lain/terkait

Lampiran Berkas

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