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Electronic Resource

Sequential experimentation in clinical trials: design and analysis

Bartroff, Jay - Nama Orang; Lai, Tze Leung - Nama Orang; Shih, Mei-Chiung - Nama Orang;

Sequential Experimentation in Clinical Trials: Design and Analysis is developed from decades of work in research groups, statistical pedagogy, and workshop participation. Different parts of the book can be used for short courses on clinical trials, translational medical research, and sequential experimentation. The authors have successfully used the book to teach innovative clinical trial designs and statistical methods for Statistics Ph.D. students at Stanford University. There are additional online supplements for the book that include chapter-specific exercises and information.
Sequential Experimentation in Clinical Trials: Design and Analysis covers the much broader subject of sequential experimentation that includes group sequential and adaptive designs of Phase II and III clinical trials, which have attracted much attention in the past three decades. In particular, the broad scope of design and analysis problems in sequential experimentation clearly requires a wide range of statistical methods and models from nonlinear regression analysis, experimental design, dynamic programming, survival analysis, resampling, and likelihood and Bayesian inference. The background material in these building blocks is summarized in Chapter 2 and Chapter 3 and certain sections in Chapter 6 and Chapter 7. Besides group sequential tests and adaptive designs, the book also introduces sequential change-point detection methods in Chapter 5 in connection with pharmacovigilance and public health surveillance. Together with dynamic programming and approximate dynamic programming in Chapter 3, the book therefore covers all basic topics for a graduate course in sequential analysis designs.


Ketersediaan
#
Perpustakaan Pusat E535
E535
Tersedia
Informasi Detail
Judul Seri
Springer Series in Statistics
No. Panggil
E535
Penerbit
New York : Springer New York., 2012
Deskripsi Fisik
xvi, 240hlm.
Bahasa
English
ISBN/ISSN
9781461461142
Klasifikasi
NONE
Tipe Isi
-
Tipe Media
computer
Tipe Pembawa
online resource
Edisi
1
Subjek
Statistik
Analisis Regresi
uji klinis
Info Detail Spesifik
-
Pernyataan Tanggungjawab
Jay Bartroff, Tze Leung Lai, Mei-Chiung Shih
Versi lain/terkait

Tidak tersedia versi lain

Lampiran Berkas
  • Sequential experimentation in clinical trials: design and analysis
    https://doi.org/10.1007/978-1-4614-6114-2
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